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A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

Research study of NT-175 for Advanced Solid Tumors with TP53 R175H Mutation

Recruiting
18 years and older
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates advanced solid tumors that are positive for the TP53 R175H mutation. The purpose of this study is to evaluate the investigational medication NT-175 in these tumors.

The study evaluates the safety and preliminary antitumor activity of NT-175. It focuses on understanding how the investigational medication works in different types of solid tumors.

  • Who can participate: Adults aged 18 and older with advanced solid tumors positive for the TP53 R175H mutation and HLA-A*02:01. Participants must have undergone prior treatment and have no curative options available.
  • Study details: Participants will receive NT-175, an investigational medication. Some may receive a placebo, which is an inactive substance that looks like the investigational medicine but does not contain any medicine.
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Study details
    Non-small Cell Lung Cancer
    Head and Neck Squamous Cell Carcinoma
    Colorectal Carcinoma
    Pancreatic Adenocarcinoma
    Breast Cancer
    Other Solid Tumors
    Ovarian Cancer
    Myeloid Neoplasms (AML/MDS)

NCT05877599

AstraZeneca

5 September 2026

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