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Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer

Investigating Gut Microbiome Modulation in Resectable Pancreatic Cancer

Recruiting
19 years and older
All
Phase 2

This study investigates resectable pancreatic cancer. It explores how the gut microbiome is affected by treatment with antibiotics and an investigational medication after chemotherapy.

The purpose of this study is to evaluate the immune response and safety of combining antibiotics with an investigational medication. It looks at how these treatments may impact the cancer and the body's immune system.

  • Who can participate: Adults over 18 years with resectable pancreatic cancer and a good performance status can participate. They must agree to biopsies and surgical procedures.
  • Study details: Participants will receive antibiotics and an investigational medication after chemotherapy.
  • Study timelines: The study will last 5 years. Participant involvement is 6 months.
Study details
    Pancreatic Cancer

NCT05462496

Icahn School of Medicine at Mount Sinai

31 July 2026

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