Image

A Beta-only IL-2 ImmunoTherapY Study

Study on Investigational Medication for Advanced Solid Tumors

Recruiting
18 years and older
All
Phase 1/2

This study investigates advanced solid tumors. It evaluates the safety and tolerability of an investigational medication called MDNA11, which is a long-acting "beta-only" recombinant interleukin-2.

The study focuses on evaluating the safety and effectiveness of MDNA11 alone or in combination with a checkpoint inhibitor. It looks at how well this investigational medication works and how the body responds to it.

  • Who can participate: Participants must be at least 18 years old with an ECOG Performance Status of 0 to 1. They should have a confirmed diagnosis of advanced or metastatic solid tumors and a life expectancy of at least 12 weeks.
  • Study details: Participants will receive MDNA11, either alone or with a checkpoint inhibitor.
Study details
    Advanced Solid Tumor
    Unresectable Solid Tumor
    Clear Cell Renal Cell Carcinoma
    Triple Negative Breast Cancer
    Non-Small Cell Lung Cancer Squamous
    Non-Small Cell Lung Cancer Non-squamous
    Colorectal Cancer (MSI-H)
    Gastric Cancer
    Cervical Cancer
    Basal Cell Carcinoma
    Bladder Cancer
    Merkel Cell Carcinoma
    Squamous Cell Carcinoma of Head and Neck
    Cutaneous Squamous Cell Carcinoma
    Pleural Mesothelioma
    Esophageal Cancer
    Endometrial Carcinoma
    Solid Tumor
    Solid Tumor
    Adult
    MSI-H Solid Malignant Tumor
    Cancer With A High Tumor Mutational Burden
    Epithelial Ovarian Carcinoma
    Primary Peritoneal Cancer
    Gastroesophageal Junction (GEJ) Cancer
    Acral Melanoma
    Mucosal Melanoma
    Cutaneous Melanoma
    DMMR Solid Malignant Tumor
    Fallopian Tube Cancer
    Ovarian Cancer
    MSI-H Cancer
    DMMR Cancer
    Pancreas Adenocarcinoma (MSI-H)
    Skin Cancer
    Viral Cancer
    Cervical Cancers
    Endometrial Cancer

NCT05086692

Medicenna Therapeutics, Inc.

17 October 2026

Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team


Email

View email

Phone

Phone country flag

View phone
Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.