Image

KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer

Investigational Vaccine Study for Advanced Colorectal and Pancreatic Cancer

Recruiting
18 years and older
All
Phase 1

This study investigates advanced colorectal cancer and pancreatic ductal adenocarcinoma. It involves patients with these conditions who have already undergone first-line chemotherapy.

The study evaluates the effects of a vaccine targeting KRAS mutations when combined with two other investigational medications. It focuses on understanding the immune response and the overall effectiveness of this combination treatment.

  • Who can participate: Adults aged 18 and older with colorectal or pancreatic cancer that cannot be surgically removed can participate. They must have specific KRAS mutations and have previously received chemotherapy.
  • Study details: Participants will receive a vaccine and two investigational medications. A placebo is not used in this study.
Study details
    Colorectal Cancer
    Pancreatic Cancer

NCT06411691

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

8 August 2026

Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team


Email

View email

Phone

Phone country flag

View phone
Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.