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CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors

Investigational Medication for Advanced Solid Tumors

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates solid tumors. It looks at how an investigational medication combined with hydroxychloroquine and either 5-fluorouracil or gemcitabine affects these tumors.

The study evaluates the overall response rate, progression-free survival, and safety of the treatment. It focuses on how the combination works in managing advanced solid tumors.

  • Who can participate: Adults 18 and older with advanced solid tumors that have not responded to standard treatments may participate. Participants must meet specific health criteria and have certain types of cancer, such as colorectal, pancreatic, or gastroesophageal.
  • Study details: Participants will receive an investigational medication with hydroxychloroquine and either 5-fluorouracil or gemcitabine.
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Study details
    Advanced Biliary Tract Carcinoma
    Advanced Colorectal Carcinoma
    Advanced Gastroesophageal Junction Adenocarcinoma
    Advanced Lung Adenocarcinoma
    Advanced Malignant Solid Neoplasm
    Advanced Ovarian Carcinoma
    Advanced Pancreatic Carcinoma
    Advanced Urothelial Carcinoma
    Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
    Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
    Metastatic Biliary Tract Carcinoma
    Metastatic Colorectal Carcinoma
    Metastatic Gastroesophageal Junction Adenocarcinoma
    Metastatic Lung Adenocarcinoma
    Metastatic Ovarian Carcinoma
    Metastatic Pancreatic Carcinoma
    Metastatic Urothelial Carcinoma
    Refractory Biliary Tract Carcinoma
    Refractory Colorectal Carcinoma
    Refractory Gastroesophageal Junction Adenocarcinoma
    Refractory Lung Adenocarcinoma
    Refractory Ovarian Carcinoma
    Refractory Pancreatic Carcinoma
    Refractory Urothelial Carcinoma
    Stage II Pancreatic Cancer AJCC v8
    Stage III Colorectal Cancer AJCC v8
    Stage III Lung Cancer AJCC v8
    Stage III Ovarian Cancer AJCC v8
    Stage III Pancreatic Cancer AJCC v8
    Stage IV Colorectal Cancer AJCC v8
    Stage IV Lung Cancer AJCC v8
    Stage IV Ovarian Cancer AJCC v8
    Stage IV Pancreatic Cancer AJCC v8

NCT05733000

Northwestern University

17 April 2026

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