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KRAS Neoantigen Nanovaccine as Adjuvant Therapy for Colorectal Cancer/Pancreatic Cancer

Investigational Vaccine for Colorectal and Pancreatic Cancer with KRAS Mutations

Recruiting
18-75 years
All
Phase 1/2

This study investigates colorectal and pancreatic cancer with KRAS mutations. The purpose is to use a vaccine made from a special type of bacteria to help patients after surgery.

The study evaluates the safety and how well the vaccine works in the body. It looks at how the body reacts and if the vaccine helps protect against cancer returning.

  • Who can participate: Adults aged 18 to 75 with colorectal or pancreatic cancer, specific KRAS mutations, and who have completed surgery and chemotherapy may join.
  • Study details: Participants will receive a vaccine made from a special bacteria. Some will also receive another medicine to evaluate their combined effects. A placebo is an inactive substance that looks like the investigational medicine but does not contain any medicine.
  • Study visits: The study requires 9 visits.
Study details
    Colorectal Cancer
    Pancreatic Cancer

NCT07353645

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

31 July 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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