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Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer

Study of the Safety and Tolerability of an Investigational Medication Combination for Advanced Unresectable Pancreatic Cancer

Recruiting
18 years and older
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates advanced unresectable pancreatic cancer. The purpose of this study is to explore how safe and tolerable a combination of investigational medications is for patients with this condition.

The study evaluates the safety and tolerability of the investigational combination. It also looks at how the combination affects progression-free survival, overall survival, and quality of life.

  • Who can participate: Adults aged 18 and older with advanced unresectable pancreatic ductal adenocarcinoma may participate. Participants must have measurable or evaluable disease, an ECOG status of 0-1, and must have recovered from any prior therapy.
  • Study details: Participants will take the investigational medication combination and undergo regular imaging scans and blood tests.
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Study details
    Advanced Pancreatic Adenocarcinoma
    Stage III Pancreatic Cancer AJCC v8
    Stage IV Pancreatic Cancer AJCC v8
    Unresectable Pancreatic Ductal Adenocarcinoma

NCT06454383

City of Hope Medical Center

31 July 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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