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LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

Investigating Cancer Cachexia in Patients with Unresectable or Stage IV Colorectal, Lung, or Pancreatic Cancer

Recruiting
18 years and older
All
Phase N/A

The purpose of this study is to investigate cancer cachexia in patients with colorectal, lung, or pancreatic cancer. This study evaluates different aspects of cancer cachexia, including symptoms, physical function, and blood markers. Researchers investigate the various subtypes of this condition to improve diagnostic criteria and treatment strategies.

  • Who can participate: Adults aged 18 and older with unresectable or stage IV non-small cell lung cancer, pancreatic adenocarcinoma, or colorectal cancer can participate. They must be starting or have recently started first-line systemic anti-cancer therapy and have an ECOG performance status of 0 to 2. Participants need to understand and speak English.
  • Study details: Participants will complete surveys, undergo physical tests, and provide blood and tumor samples. Some will wear a device to track activity. No placebo is involved in this study.
Study details
    Advanced Colorectal Carcinoma
    Advanced Lung Non-Small Cell Carcinoma
    Advanced Pancreatic Adenocarcinoma
    Stage IV Colorectal Cancer AJCC v8
    Stage IV Lung Cancer AJCC v8
    Stage IV Pancreatic Cancer AJCC v8
    Unresectable Colorectal Carcinoma
    Unresectable Lung Non-Small Cell Carcinoma
    Unresectable Pancreatic Adenocarcinoma

NCT06073431

University of Rochester

31 July 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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