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Cemiplimab Plus Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma

Study of Cemiplimab and Gemcitabine for Metastatic Pancreatic Adenocarcinoma

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the treatment of metastatic pancreatic ductal adenocarcinoma. The purpose is to evaluate the combination of an immune checkpoint inhibitor, cemiplimab, with gemcitabine in patients who have specific genetic alterations known as SWI/SNF.

The study focuses on the safety and effectiveness of combining cemiplimab with gemcitabine to improve outcomes such as overall survival and response rates in patients with this condition.

  • Who can participate: Adults aged 18 and older with stage IV pancreatic ductal adenocarcinoma and specific genetic alterations are eligible. Participants must have had one previous line of therapy and meet specific health criteria.
  • Study details: Participants will receive a combination of cemiplimab and gemcitabine. Some participants may receive a placebo, which is an inactive substance that looks like the investigational medicine but does not contain any medicine.
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Study details
    Pancreatic Ductal Adenocarcinoma (mPDAC)

NCT06790602

University of California, San Diego

30 July 2026

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