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NKG2D/CLDN18.2 CAR-T(KD-496) in the Treatment of Advanced NKG2DL+/CLDN18.2+ Solid Tumors

Investigating CAR-T Cell Therapy for Advanced Solid Tumors

Recruiting
18-75 years
All
Phase 0
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the treatment of advanced solid tumors with NKG2D/CLDN18.2 CAR-T cells. The purpose of this study is to evaluate how these CAR-T cells might work in patients with these specific types of tumors.

The study focuses on understanding the safety and effectiveness of the CAR-T cells in treating these tumors. Researchers are looking at how well patients tolerate the treatment and how effective it is in managing the disease.

  • Who can participate: Adults aged 18 to 75 years with advanced solid tumors that are positive for NKG2DL/CLDN18.2 can participate. Participants must have failed or not tolerated standard treatments.
  • Study details: Participants will receive an infusion of investigational CAR-T cells. Some participants may receive a placebo, which is an inactive substance that looks like the investigational medicine but does not contain any medicine. The study will involve screening and follow-up processes.
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Study details
    Gastric Cancer
    Pancreatic Cancer
    Solid Tumor

NCT05583201

jianming xu

8 April 2026

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