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Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)

Study of Investigational Medication for Advanced Gastric, Gastroesophageal Junction, Pancreatic, and Biliary Tract Cancers

Recruiting
18 years and older
All
Phase 1/2

This study investigates advanced gastric, gastroesophageal junction, pancreatic ductal, and biliary tract carcinomas. The purpose of this study is to evaluate the investigational medication as a potential treatment option for these conditions.

The study focuses on assessing the safety, tolerability, and initial effectiveness of the investigational medication. Researchers will gather information on how the body processes the medication and its effects on the body.

  • Who can participate: Adults aged 18 and older with advanced or metastatic gastric, gastroesophageal junction, pancreatic, or biliary tract cancers may be eligible. Participants must have measurable disease, an ECOG performance status of 0-1, and adequate organ function.
  • Study details: Participants will receive the investigational medication, with some receiving it alongside standard chemotherapy treatments. A placebo may be used in some parts of the study.
Study details
    Gastric or Gastroesophageal Junction Adenocarcinoma
    Pancreatic Ductal Adenocarcinoma
    Biliary Tract Cancer (BTC)

NCT05482893

Phanes Therapeutics

31 July 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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