This study is exploring why certain sickle cell patients, especially those with **SC** type, may get more severe forms of dengue, a disease spread by mosquitoes. **Sickle cell disease (SCD)** is a blood disorder where red blood cells are shaped like a sickle instead of donuts, which can cause health problems. Dengue can cause high fever and bleeding issues. Researchers will compare the body's response to dengue in patients with different types of sickle cell disease (**SS** and **SC**) and in those without it (hemoglobin **AA**). They will study blood cells and their reactions to the dengue virus and mosquito saliva. This might help in understanding why SC patients are at higher risk. **Key Points:** - **Length:** The study duration is not specified but involves in-depth lab analysis. - **Eligibility:** Patients aged 6-25 with specific sickle cell types or control group. - **Location:** Conducted in Guadeloupe, participants need to be part of the national social security system. **Consider joining if you meet the criteria and want to help advance knowledge on dengue and sickle cell interactions.**