This study is for people with Sickle Cell Disease (SCD) who need regular blood transfusions. Blood transfusions involve giving you new blood from a donor to help your body. In this study, we try to match your blood with the donor's blood more closely using something called RH genotype. The RH genotype is a way to check if your blood and the donor's blood are very similar, which helps make the transfusions safer.

The study will last up to three years or as long as you need regular transfusions. If the special matched blood isn’t available, you will still receive normal matched blood. We want to find out if matching blood this way helps prevent problems like making new antibodies that can attack the new blood cells.

• Study Duration: Up to 3 years or until transfusions are no longer needed.
• Visits: Regular visits for blood transfusions and monitoring.
• Eligibility: Must be over 6 months old and have SCD.

If you join, your safety is important, and you will receive blood transfusions that match your needs as closely as possible. Make sure to talk to your doctor and understand all the details before joining the study.