This study is looking at dronabinol, a medicine similar to a chemical in marijuana, to see if it helps with pain and swelling in people with sickle cell disease (SCD). SCD is a condition where your red blood cells are shaped like a sickle, and this causes pain and other problems. The study is randomized (participants are randomly picked to get the treatment or not) and double-blind (neither the participants nor the researchers know who gets the treatment).

The main goal is to find out if dronabinol can make pain and quality of life better for adults with SCD. The study will also check if dronabinol affects inflammation, which is the body's way of reacting to injury or illness.

• Participants must be over 18 years old and have SCD.
• If you're using opioids or other SCD treatments, you must have been on the same dose for 3 months.
• You should not be pregnant or using cannabis during the study.