Sickle cell disease (SCD) is a condition people are born with, which affects hemoglobin, a protein in red blood cells (RBCs) that carries oxygen. In SCD, the hemoglobin is different because of a change in the HBB gene, causing RBCs to become sickle-shaped and less efficient at carrying oxygen. This can lead to anemia, a condition where you don't have enough healthy red blood cells, and vaso-occlusive crisis (VOC), which can cause pain and hospital visits. This study is trying to find out if blood tests can help predict when VOC might happen in people with SCD.

• The study is only for those with sickle cell disease, and you must be 18 or older.
• It does not include pregnant individuals or those under legal guardianship.
• Participation may involve routine blood tests to check for VOC predictors.

Consider joining if eligible, as this research could help improve SCD management and reduce hospital visits related to VOC.