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Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

Methylphenidate may help focus and thinking in kids with Sickle Cell.

Recruiting
8-17 years
All
Phase 1

This study aims to help children with sickle cell disease (SCD) who may have trouble with attention, memory, and decision-making. Sickle cell disease is a blood disorder that can cause pain and other health issues. The study will test a medicine called Methylphenidate (MPH) to see if it can improve thinking and schoolwork in these children. Methylphenidate is a medication often used to help people pay attention and control their behavior.

Thirty children, ages 8 to 17, will take the medicine once a day for 4 weeks. Caregivers will help track any changes in thinking abilities and watch for side effects. The study will also interview caregivers to understand their decisions about using this medicine.

  • Study lasts for 4 weeks with daily medication.
  • Participants must visit the clinic initially, then take the medicine at home.
  • Potential side effects and benefits will be carefully monitored and discussed.
Study details
    Sickle Cell Disease
    Executive Dysfunction
    Cognitive Impairment
    Attention Deficit/Hyperactivity Disorder (ADHD)

NCT07226219

St. Jude Children's Research Hospital

12 September 2026

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