This study aims to see if **virtual reality (VR)** can help reduce pain in children with sickle cell disease during a **vaso-occlusive pain crisis**. A vaso-occlusive pain crisis occurs when blood flow is blocked, causing severe pain. VR is a computer-generated experience that feels real, often using goggles to immerse the user in a different world. The study will compare standard pain treatments with standard treatments plus a daily VR session to see if VR can lessen pain and reduce the use of strong pain medicines called **opiates**.

• Patients will stay in the hospital for the study and participate for up to 3 days.
• Participants will fill out surveys multiple times a day about pain and any side effects.
• Patients enrolled in the VR group will have a daily VR session to see if it helps with pain.

Eligible participants must be between 8 to 21 years old and able to use VR equipment. They must not have certain medical conditions or cognitive issues that prevent VR use. Parental consent is required for children to join. This study does not include any follow-up phase after the 3-day participation period.