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A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

Testing Crizanlizumab for sickle cell crises in teens and adults.

Recruiting
12 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

The study is researching how well a drug called crizanlizumab works and how safe it is for people with Sickle Cell Disease (SCD). SCD is a condition where red blood cells, which usually carry oxygen, become sickle-shaped and block blood flow, causing pain known as vaso-occlusive crises (VOCs). The study compares crizanlizumab to a placebo (a pill with no medicine) and involves participants aged 12 and older who have had 4-12 VOCs in the past year.

Participants may or may not be taking another medicine called hydroxyurea/hydroxycarbamide (HU/HC) to manage their condition. Participation involves random assignment to receive either crizanlizumab or placebo. The study aims to ensure that the drug is effective and safe for frequent VOC sufferers.

  • Duration: Participants will be part of the study for at least 52 weeks.
  • Visits: Regular visits for monitoring are required throughout the study.
  • Compensation: Details on compensation for participation should be confirmed with the study team.
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Study details
    Sickle Cell Disease

NCT06439082

Novartis Pharmaceuticals

17 October 2026

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