**Pilot Study "AHSP as a Biomarker of Sickle Cell Disease in Adults and Children"** This study looks at AHSP (Alpha Hemoglobin Stabilizing Protein) levels in blood to see if it can help identify sickle cell disease. Sickle cell disease is a condition where red blood cells become misshaped and can block blood flow. The study involves adults and children with sickle cell disease and compares them to healthy people. It's important to know that this research is non-interventional, meaning it doesn't involve any treatment; it's just observation and testing. Scientists will take small blood samples from participants, which will be stored at very cold temperatures (-80°C). These samples are then brought to a lab where DNA is prepared, and testing is done to measure AHSP levels. The goal is to compare these levels among different groups and find connections with other health factors. **Key Points:** - **No treatment involved:** The study is observational, so there’s no medication or therapy given. - **Blood samples are a part of regular care:** Participants provide blood samples already planned for their medical care. - **Eligibility is specific:** Participants need to meet certain age and health criteria. The study helps understand more about sickle cell disease, but it's important to consider if you meet the criteria and are comfortable with the procedures.