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Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults

Testing ketamine for pain relief in children and young adults.

Recruiting
5-20 years
All
Phase 2
**Research on Ketamine for Treating Sickle Cell Pain in Kids and Young Adults** *Ketamine* is a medicine that can help with pain. This study checks if a small amount of ketamine is safe and works well for pain in children and young adults (ages 5-20) with *sickle cell disease* (a blood condition causing pain due to blocked blood flow, known as vaso-occlusive pain events or VOE). Patients will get either regular pain medicine like morphine or the same medicine with a low dose of ketamine. **Key Points:** - The study involves one additional dose of ketamine along with standard pain treatment. - Participants need to speak English or Spanish. Consent from a guardian is required, with the child's agreement if possible. - Those with certain health issues or pregnant individuals cannot join the study. This study will help determine if adding ketamine to regular pain treatments can better relieve sickle cell-related pain. Participation means contributing to research that could improve therapies for sickle cell disease. **HTML tags for web page formatting:** html

Research on Ketamine for Treating Sickle Cell Pain in Kids and Young Adults

Ketamine is a medicine that can help with pain. This study checks if a small amount of ketamine is safe and works well for pain in children and young adults (ages 5-20) with sickle cell disease (a blood condition causing pain due to blocked blood flow, known as vaso-occlusive pain events or VOE). Patients will get either regular pain medicine like morphine or the same medicine with a low dose of ketamine.

  • The study involves one additional dose of ketamine along with standard pain treatment.
  • Participants need to speak English or Spanish. Consent from a guardian is required, with the child's agreement if possible.
  • Those with certain health issues or pregnant individuals cannot join the study.

This study will help determine if adding ketamine to regular pain treatments can better relieve sickle cell-related pain. Participation means contributing to research that could improve therapies for sickle cell disease.

Study details
    Sickle Cell Disease
    Vaso-Occlusive Pain Episode in Sickle Cell Disease
    Ketamine Infusion
    Pain Management
    Vaso-Occlusive Crises

NCT07369024

Mohsen Saidinejad

12 September 2026

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