Study Overview: This research is checking if L-Citrulline, given through a vein (intravenous), helps with pain for kids and young adults (ages 4-21) who have sickle cell disease (a blood problem causing pain). When people with sickle cell have a lot of pain, they often need strong medicine in the hospital. This study will see if L-Citrulline can help make the pain go away faster. It compares L-Citrulline to a placebo (a fake treatment) to see if it really works.
What's Involved:
- Participants will get L-Citrulline for 16 hours in the hospital.
- A follow-up visit happens about 30 days after leaving the hospital.
- The study checks for any side effects and how much pain medicine is needed.
- This study lasts about a month, including a hospital stay and a follow-up visit.
- Participants must be 4-21 years old and have sickle cell disease.
- They may receive a placebo instead of L-Citrulline.
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