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Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET

Studying heart perfusion and function in sickle cell patients with PET.

Recruiting
18-21 years
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at how the heart is affected by Sickle Cell Disease (SCD). SCD may cause heart damage due to reduced blood flow during stress. The study also includes people without SCD to compare heart reactions.

Myocardial Perfusion means blood flow to the heart muscle. Diastolic Dysfunction is when the heart has trouble relaxing and filling with blood. PET (Positron Emission Tomography) is a type of imaging test that helps see how blood flows in the heart.

Participants need to attend two study visits. The first involves blood tests and heart checks, like an electrocardiogram (EKG) and an echocardiogram. The second includes a PET stress test to measure heart blood flow.

After the visits, researchers will follow up with phone calls for a week. Eligible participants are 18-21 years old and of Black ethnicity. The study excludes those with severe heart issues or recent hospital stays for SCD-related conditions.

  • Two visits are required: involving blood tests, EKG, echocardiogram, and a PET stress test.
  • Participants will be followed up for one week after the study tests.
  • Excludes individuals with severe heart issues or recent hospitalizations.
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Study details
    Sickle Cell Disease

NCT05583721

St. Jude Children's Research Hospital

17 April 2026

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