This study is about collecting information from patients with non-cancer disorders who are undergoing a type of treatment called hematopoietic stem cell transplantation (HSCT). This treatment uses healthy donor cells to help cure or improve certain diseases. The study focuses on a specific way of preparing patients for this treatment, called reduced-intensity conditioning (RIC), which uses less intense chemotherapy to make the body ready for the new cells. The aim is to find out how well the treatment works and how safe it is.

To join, you must be between 2 months and 60 years old and have a disorder that can be treated with stem cell transplantation. These disorders include certain immune system problems, bone marrow failures, metabolic disorders, anemias, and inflammatory conditions. During the study, patients receive a transplant from umbilical cord blood, bone marrow, or peripheral blood stem cells, along with medicines to help the process.

• The study takes place at UPMC Children's Hospital of Pittsburgh.
• There are no specific reasons to be excluded from the study.
• Participants will help researchers learn more about this treatment's success and safety.