Sickle Cell Disease (SCD) is a blood disorder where red blood cells, which carry oxygen, are shaped like sickles or crescent moons. This can cause pain and other serious health problems. This study aims to help young people aged 12-25 with SCD by teaching them how to be more resilient, which means being able to handle challenges better. The study uses a method called the Collaborative Care Model (CoCM), where different health professionals work together to support patients.

The study will take place at the Dana-Farber Cancer Institute/Boston Children's Hospital (DFCI/BCH) and includes 25 participants. The main goal is to see if the resilience program, called PRISM, is practical and liked by the participants. The study also looks at how the program might help with depression, anxiety, and pain. Participants will need to attend sessions and complete surveys, and they must be able to speak and read English or Spanish.

• The study will be conducted at a well-known hospital setting, ensuring professional care.
• Participants must attend sessions and complete surveys, which require time commitment.
• Potential benefits include improved mental health and coping skills.