This study checks how well a special tool, a cutaneous hydration sensor, works to measure skin moisture in people with Sickle Cell Disease (SCD). The **cutaneous hydration sensor** is a tool used on the skin to check how much water is in the skin. This helps doctors decide the best way to give fluids to patients, especially during a **vaso-occlusive episode (VOE)**, a painful event common in SCD that can lead to hospitalization. Sometimes giving too much fluid can cause problems like **hypervolemia** (too much fluid in the body) and **pulmonary edema** (fluid in the lungs), which can be dangerous. The study wants to see if this sensor can help avoid such problems.

• **Key Point 1:** Only people 12 years or older with SCD can join.
• **Key Point 2:** The study involves measuring skin moisture and comparing it with blood and urine tests.
• **Key Point 3:** Participants must agree to all study procedures and not be in other clinical trials.