Sickle cell disease is a genetic disorder affecting blood, causing red blood cells to become sickle-shaped. This can lead to various problems, like pain and organ damage. In this study, researchers want to learn more about megakaryocytes, which are large bone marrow cells that produce platelets (small blood cells that help with clotting). These megakaryocytes might play a role in the inflammation seen in sickle cell disease.
Researchers will collect blood samples from adults with sickle cell disease to study their megakaryocytes. They want to compare samples from patients who are feeling stable and those experiencing sickle cell crises, like acute chest syndrome, which affects the lungs.
- Duration & Participation: Blood samples from 40 patients will be collected.
- Eligibility: Participants must be 18+, have sickle cell disease, and meet other criteria.
- Exclusions: Other blood disorders, recent transfusions, or certain medications.
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