Virtual Reality for Pain Relief in Sickle Cell Crisis This study is testing if using virtual reality (VR) can help reduce pain for adults with sickle cell disease during a vaso-occlusive crisis, which is when blood flow is blocked, causing pain. The study is happening at the University of Maryland Medical Center in Baltimore. Participants must be at least 18 years old, have sickle cell disease, and be in the emergency department due to a pain crisis. The study excludes those who have been in the study before or have certain medical issues. Once in the study, participants will use a VR device for up to 2 hours. Their pain will be assessed at four times: before using VR, 1 hour into use, immediately after, and 1 hour later. They'll rate their pain on a scale from 0 to 10. The study will also check how comfortable the device is, how long patients stay in the emergency department, and how much pain medication they need.

• The study takes place in an emergency department.
• VR sessions last a maximum of 2 hours.
• Participants assess their pain at four different times.

It’s important to note that participation is voluntary, and participants will be asked about their experience with VR.