Sickle cell disease (SCD) is a genetic condition that affects how red blood cells work. It can cause symptoms like **chronic anaemia** (low red blood cells), **vaso-occlusive crisis** (VOC, which is painful blockages in blood vessels), and damage to organs. This study looks at how regular exercise can help people with SCD feel better and improve their fitness levels.

Participants in the study will do regular moderate-intensity exercise over a year to see if it reduces VOCs and hospital visits. The study involves multiple visits for evaluations and tests to monitor changes in fitness and health. The aim is to show that exercise is safe and beneficial for those with SCD.

• **Study Duration:** The study lasts for one year with several visits over this period.
• **Participation Requirements:** You must be 15 years or older, have SCD, and not currently exercise regularly.
• **Benefits and Risks:** The study hopes to improve physical health, but participants will be monitored for any risks from exercise.