Sickle Cell Disease (SCD) is a blood disorder that can cause severe pain due to vaso-occlusive crises (VOCs), when blood flow is blocked. This study compares two ways of giving IV (intravenous) fluids: restrictive (less fluid) and liberal (more fluid), to see which is better for managing pain during a VOC. An open-label study means both doctors and patients know which treatment is being given. Participants, aged 18 or older with SCD, will be randomly assigned to one of the fluid strategies. The main goal is to see how well each strategy reduces pain. Other things being looked at include time for pain to go away, hospital stay length, and any side effects like fluid overload or kidney problems. The study takes place in emergency rooms in Saudi Arabia and follows patients for up to 28 days.

• This study involves random assignment to either restrictive or liberal fluid strategy.
• Participants will be monitored closely for up to 28 days.
• Informed consent is required to participate.