Study Overview: This research is designed to find out if a medication called ZED1227 can help people who have celiac disease but still feel sick even when they avoid gluten.

Key Points to Consider:

• Participants must be between 18 and 80 years old and have been on a gluten-free diet for at least a year.
• The study excludes those with severe celiac disease complications or other intestinal diseases.
• Participants' safety and medicine's effectiveness will be closely monitored.

Definitions:

Celiac Disease: A condition where the body reacts badly to gluten, a protein found in wheat, rye, and barley, causing stomach pain and other issues.

Gluten-Free Diet (GFD): A diet that avoids all foods containing gluten.

Human Leukocyte Antigen DQ (HLA-DQ): A genetic marker that helps doctors confirm celiac disease.

Eligibility: Participants need to have a confirmed celiac disease diagnosis and have been gluten-free for a year. Those with well-controlled thyroid disorders or mild celiac symptoms may still qualify.