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Tryptophan for Impaired AhR Signaling in Celiac Disease

Exploring tryptophan's role in celiac disease through clinical trials.

Recruiting
18-75 years
All
Phase N/A

Tryptophan is an important amino acid, a building block of proteins, that our body needs. This study is testing how L-tryptophan affects people with celiac disease (CeD)gluten-free diet (GFD) for a year. This study includes 50 participants, aged 18 to 75, who will take either L-tryptophan or a placebo (a pill with no active medicine) for three weeks.

Participants will visit the clinic three times. At the start, they will get all their study pills and learn about a special diet. They will fill out questionnaires about their diet and symptoms, give blood, stool, and urine samples, and have a small medical procedure called an endoscopy to check their intestine.

  • The study lasts for 3 weeks.
  • Participants will need to visit the clinic 3 times.
  • This study includes medical procedures like endoscopy.
Study details
    Tryptophan Metabolism Alterations
    Celiac Disease

NCT05576038

McMaster University

17 April 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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