Celiac disease is a condition where the body's immune system reacts badly to gluten, a protein found in wheat and other grains. This study is about how kids with celiac disease respond when given small amounts of gluten. Kids aged 8-14 years, who have been on a strict gluten-free diet for at least 18 months, can join. They will be split into three groups: one gets a placebo (a pill with no gluten), another gets 50 mg of gluten, and the last gets 5 g. They take this once daily for three days. Blood, stool, and urine samples will be collected before and after the gluten intake to see how their immune systems react. The study uses special tools like RNA sequencing (a way to see which genes are active) to look at immune cells. This helps researchers understand if even tiny amounts of gluten can cause a reaction.
- The study lasts for about 8 days with two visits for sample collection.
- Participants must be on a gluten-free diet and have no severe reactions to gluten.
- No direct treatment is involved, but the study helps in understanding immune responses.