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Safety Comparison of Total Laparoscopic Proximal Gastrectomy With or Without Preservation of the Celiac Branch of the Vagus Nerve for Early Upper Gastric Cancer: A Randomized Controlled Clinical Trial

Comparing safety of two surgical methods for early upper stomach cancer.

Recruiting
18-75 years
All
Phase N/A

This study is looking at a type of surgery called total laparoscopic proximal gastrectomy (TLPG) for patients with early upper gastric cancer. The surgery focuses on whether to keep a part of the vagus nerve, which helps control the stomach. The main goal is to see how well the stomach empties food six months after surgery. Other things the study checks include the chance of developing reflux esophagitis (a condition where stomach acid irritates the esophagus), overall quality of life, and survival without disease for three years.

Patients in the study will be randomly placed into two groups: one where both the hepatic and celiac branches of the vagus nerve are kept, and another where only the hepatic branch is kept. The study will help doctors understand if keeping both branches makes a difference in recovery.

  • The study will last for at least three years.
  • Participants will undergo surgery and follow-ups.
  • Outcomes may affect future surgical techniques.
Study details
    Gastric Cancer

NCT07142122

Fujian Cancer Hospital

17 April 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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