Celiac disease (CD) is a disease where eating gluten, a protein in wheat, rye, and barley, causes problems. This study aims to understand how genes, the environment, gut bacteria (microbiome), and substances made in our bodies (metabolites) affect the development of CD in children. By studying kids with a close family member with CD, researchers hope to find ways to predict and prevent the disease.

Genomic: This involves studying genes like HLA DQ2 and DQ8, which are known to play a role in CD but can't predict it alone.

Environmental: Researchers will track infants’ birth details, antibiotic use, and feeding habits to see if these impact CD development.

Microbiome: The study will examine gut bacteria to see how they might affect CD development.

Metabolomic: Researchers will look at the substances produced during digestion to identify any patterns linked to CD.

• Study is for infants under 6 months old with a family member who has CD.
• Participation involves regular updates every six months until the child is 5 years old.
• Legal guardian consent is required for participation.