This study investigates early screening methods for Type 1 diabetes (T1D) and celiac disease (CD) in individuals at risk due to family history or other autoimmune conditions. Type 1 diabetes is a chronic disease where the body's defense system mistakenly attacks specific cells within the pancreas, which make insulin. Insulin helps control sugar in the blood. When these cells are damaged, they cannot make enough insulin. This means people with Type 1 diabetes need to take insulin every day to keep their blood sugar at safe levels.

Participants in the study will undergo screening processes to identify early signs of T1D or CD, even before symptoms appear. The study aims to improve screening methods to ensure accurate diagnosis and appropriate treatment, distinguishing between T1D and other forms of diabetes such as Type 2 diabetes, which requires different care.

• Who can participate: Eligible participants are children over 2 years old and adults at high risk of Stage 3 T1D. They must have a family history of T1D or another autoimmune disease, or a BMI ≤28 with progression to insulin dependence within 3 years.
• Study details: Participants will undergo screening to detect early signs of T1D or CD. The study aims to improve screening and ensure accurate diagnosis to differentiate T1D from other diabetes forms.