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L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML

Testing a new treatment for adults with hard-to-treat AML.

Recruiting
18-80 years
All
Phase 2/3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study tests a new treatment for adults with a type of blood cancer called acute myeloid leukemia (AML). The study looks at how well two different doses of a drug called L-Annamycin work with another drug called Cytarabine. Participants must have AML that has returned (relapsed) or not responded (refractory) after one treatment.

The study has two parts. In Part A, doctors will figure out the best dose of L-Annamycin. In Part B, they will use that dose to compare it with a placebo (a substance with no active drug) in more people. Participants are randomly placed into different groups, and some will receive the placebo instead of L-Annamycin.

  • The study includes two parts, with each part testing different doses.
  • Participants receive intravenous (IV) infusions over several days.
  • The study involves multiple centers and will include up to 312 adults with AML.

Participants should discuss any potential risks with their doctor before joining.

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Study details
    Acute Myeloid Leukaemia (AML)

NCT06788756

Moleculin Biotech, Inc.

17 October 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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