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DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemoimmunotherapy

Join a study comparing new and standard treatments for advanced lung cancer.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

In this study, adults with advanced Small Cell Lung Cancer (SCLC) will participate. The main goal is to see if a new medicine called obrixtamig, used with standard treatments (atezolizumab, carboplatin, and etoposide), helps patients live longer compared to the standard treatments alone. Obrixtamig is a special molecule that might help the body's defense system fight cancer. Participants are divided into two groups randomly: one group receives obrixtamig with the standard treatment, and the other group gets only the standard treatment. All medicines are given through a vein.

Participants will be in the study for up to three years and need to visit the study site regularly. If they are in the obrixtamig group, they must stay overnight for the first two treatments. Doctors will check the tumor size and participant health frequently.

  • Study duration: Up to 3 years
  • Regular site visits required
  • First two treatments may require overnight stay for some participants
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Study details
    Small Cell Lung Cancer (SCLC)
    Extensive-stage Small Cell Lung Cancer (ES-SCLC)

NCT07472517

Boehringer Ingelheim

10 October 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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