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NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

NRSTS2021: Study on treatment options for soft tissue sarcoma.

Recruiting
30 years and younger
All
Phase 1/2
This study is for people aged 1 to 30 who have a type of cancer called **non-rhabdomyosarcoma soft tissue sarcoma (NRSTS)**. It will test a combination of medicines and treatments to see which work best. The study will use drugs like **pazopanib**, **selinexor**, **ifosfamide**, and **doxorubicin**. These drugs help stop cancer cells from growing. Some patients might also have surgery or radiation therapy. **Key Points:** - **Study Length:** This study involves various treatments and might require hospital visits and follow-ups. - **Eligibility:** You must meet certain health requirements to join, like good heart and lung function. - **Risks & Benefits:** There could be side effects from drugs. The study might help find better ways to treat NRSTS. Before joining, you should discuss all risks, benefits, and requirements with your doctor to see if it's the right fit for you.
Study details
    Adipocytic Neoplasm
    Liposarcoma
    Atypical Fibroxanthoma
    Angiomatoid Fibrous Histiocytoma
    Fibrosarcoma NOS
    Myxofibrosarcoma
    Angiosarcoma
    Osteosarcoma
    Extraskeletal
    Dedifferentiated Liposarcoma
    Myxoid Liposarcoma
    Pleomorphic Liposarcoma
    Myxoid Pleomorphic Liposarcoma
    Low Grade Fibromyxoid Sarcoma
    Sclerosing Epithelioid Fibrosarcoma
    Malignant Tenosynovial Giant Cell Tumor of Soft Tissue
    Epithelioid Hemangioendothelioma
    Glomus Tumor
    Inflammatory Leiomyosarcoma
    Leiomyosarcoma
    Ossifying Fibromyxoid Tumor
    Malignant
    Myoepithelioma
    Synovial Sarcoma
    Epithelioid Sarcoma
    Perineurioma
    Malignant
    Clear Cell Sarcoma
    Extraskeletal Myxoid Chondrosarcoma
    Granular Cell Tumor
    Malignant
    Melanotic Malignant Nerve Sheath Tumor
    Malignant Peripheral Nerve Sheath Tumor
    Perivascular Epithelioid Tumor
    Malignant
    Intimal Sarcoma
    Myoepithelial Carcinoma
    Undifferentiated Sarcoma
    Pleomorphic Sarcoma
    Undifferentiated
    Round Cell Sarcoma
    Undifferentiated
    NTRK-Rearranged Spindle Cell Neoplasm
    Phosphaturic Mesenchymal Tumor
    Malignant
    Round Cell Sarcoma
    Well Differentiated Liposarcoma
    Giant Cell Tumor of Soft Parts NOS
    Low Grade Myofibroblastic Sarcoma
    Dermatofibrosarcoma Protuberans
    Fibrosarcomatous

NCT06239272

St. Jude Children's Research Hospital

17 October 2026

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