This study looks at how a genetic change, called LRRK2 mutation, affects people with Parkinson's disease (PD). Researchers will compare people with this mutation to those with PD but without the mutation. Participants will undergo brain scans, cognitive tests, motor tests, sensory tests, and fill out questionnaires. Positron emission tomography (PET) and magnetic resonance imaging (MRI) are types of scans that help us see inside the brain. The study aims to understand differences in brain chemicals and how they relate to movement and thinking skills in these two groups of PD patients. LRRK2 mutations are common in PD and can change how the disease progresses, sometimes leading to balance and walking problems. Understanding these changes could help create new treatments.

• Participation: Involves brain scans, tests, and questionnaires.
• Eligibility: Must be 45 or older and have PD with LRRK2 mutation.
• Exclusion: Cannot participate if pregnant, have certain medical devices, or cognitive issues.