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A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer

Study of Investigational Medication with Cancer Treatment for Pancreatic Cancer

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates pancreatic cancer. Researchers are examining how an investigational medication works when given with chemotherapy in people with this condition.

The study evaluates the effectiveness and safety of the investigational medication combined with chemotherapy. It looks at how the body processes the medication and checks for any side effects.

  • Who can participate: Adults with metastatic pancreatic cancer and a specific KRAS G12D mutation can participate. Participants must have no option for surgery or radiotherapy and should have good organ function.
  • Study details: Participants will receive either the investigational medication with chemotherapy or a placebo with chemotherapy.
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Study details
    Pancreatic Cancer
    Metastatic Pancreatic Cancer
    Metastatic Pancreatic Adenocarcinoma

NCT07409272

Astellas Pharma Global Development, Inc.

5 September 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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