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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

Investigating Chemotherapy With or Without Investigational Medication in Metastatic Pancreatic Ductal Adenocarcinoma

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates metastatic pancreatic ductal adenocarcinoma. Participants will receive chemotherapy with or without an investigational medication.

The study evaluates the safety and effectiveness of the treatment options. It looks at how well participants tolerate the treatments.

  • Who can participate: Adults with metastatic pancreatic ductal adenocarcinoma and a KRAS G12D mutation may join. Participants should not have had prior systemic treatment for their cancer and must have good organ function.
  • Study details: Participants will receive chemotherapy and may receive an investigational medication. Some participants may receive a placebo, which is an inactive substance that looks like the investigational medicine but does not contain any medicine.
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Study details
    Solid Tumors

NCT07522073

Incyte Corporation

17 October 2026

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