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A Study To Assess the Safety, Tolerability, and Efficacy of Imzokitug in Combination With Pumitamig and Platinum-Doublet Chemotherapy (PDCT) Versus Pumitamig and PDCT as First-line Treatment for Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Testing safety and effects of new lung cancer treatment options.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is testing a new treatment for a type of lung cancer called Non-Small Cell Lung Cancer (NSCLC). NSCLC can be "locally advanced," meaning it has grown a lot in the lung area, or "metastatic," meaning it has spread to other parts of the body. The study is comparing two treatments: one uses a new drug called Imzokitug combined with Pumitamig and a type of chemotherapy called Platinum-Doublet Chemotherapy (PDCT). The other treatment just uses Pumitamig and PDCT.

**Imzokitug** and **Pumitamig** are medicines being tested to see if they help fight cancer. The study will look at how safe these medicines are, how well patients handle them, and how well they work in treating the cancer.

  • The study is for patients with a specific stage of NSCLC who haven't had certain cancer treatments before.
  • Patients must provide tumor samples and meet specific health conditions to participate.
  • There are some health conditions and previous treatments that could prevent participation.

It's important to talk with your doctor to see if joining this study is a good choice for you.

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Study details
    Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
    Metastatic Non-Small Cell Lung Cancer (NSCLC)

NCT07680764

Bristol-Myers Squibb

17 October 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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