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Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Exploring CAR T cell therapy for challenging pediatric brain tumors.

Recruiting
1-26 years
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is for children and young adults (ages 1-26) with tough brain tumors, like Diffuse Intrinsic Pontine Glioma (DIPG) and other Central Nervous System (CNS) tumors. It uses a special type of treatment called **CAR T cell therapy**. T cells, a type of immune cell, are changed in a lab to attack tumor cells with something called B7H3. The treatment is given through a small tube (catheter) placed in the brain.

  • Study Length: The treatment includes two courses, each with doses over several weeks.
  • Visits Needed: Patients visit weekly for doses and check-ups.
  • Safety: The study checks if the treatment is safe and how well it targets tumor cells.

Participants must have no other health problems that would interfere with the study and should not be pregnant or breastfeeding. They will be closely watched to see if the therapy works and if there are any side effects.

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Study details
    Central Nervous System Tumor
    Diffuse Intrinsic Pontine Glioma
    Diffuse Midline Glioma
    Ependymoma
    Medulloblastoma
    Childhood
    Germ Cell Tumor
    Atypical Teratoid/Rhabdoid Tumor
    Primitive Neuroectodermal Tumor
    Choroid Plexus Carcinoma
    Pineoblastoma
    Childhood
    Glioma

NCT04185038

Seattle Children's Hospital

31 July 2026

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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