**Prospective Procurement of Tumor Tissue Study** Many advances have been made in cancer treatments, but more research is needed. This study aims to collect tissue and blood samples from people with known or suspected cancer to find new treatment targets. **Key Points to Consider:** - **Duration:** Participants will be in the study for 6 months and may have multiple visits. - **Procedures:** No new procedures will be performed. Tissue and blood samples will be collected during standard care surgeries or biopsies. - **Eligibility:** Adults 18 years or older with known or suspected cancer requiring surgery or biopsy. Participants will answer health questions and provide medical records. Blood samples will be tested for HIV and hepatitis B and C, and used for genetic research. Tissue samples will be collected during routine surgeries or biopsies. Some samples may be taken from past procedures. The goal is to help identify new cancer treatment targets. No investigational therapy will be given, and up to 1200 participants are expected to enroll. Participants must be willing to undergo tests and sign a consent form.