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Stereotactic Body Radiotherapy and NALIRIFOX for Locally Advanced Pancreatic Cancer

Exploring new treatments for advanced pancreatic cancer.

Recruiting
18-75 years
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

Stereotactic Body Radiotherapy (SBRT) and NALIRIFOX are being studied for treating locally advanced pancreatic cancer that can't be removed by surgery. SBRT is a special type of radiation therapy that targets tumors precisely. NALIRIFOX is a combination of drugs used in chemotherapy, including liposomal irinotecan, oxaliplatin, 5-FU, and leucovorin. This study will check if this treatment is safe and if it can help patients live longer without the cancer getting worse. The study will follow two groups: one receiving SBRT early after 1 cycle of NALIRIFOX, and the other later after 6-8 cycles.

  • Duration: 24-month follow-up.
  • Participants: 42 people, aged 18-75, with specific health criteria.
  • Requirements: No prior cancer treatments and ability to consent.

Researchers will measure progression-free survival (PFS), which is the time before the cancer worsens or the patient passes away. They will also look at how well the cancer responds to the treatment and overall survival. Safety and any side effects will be closely checked. If you decide to join, you'll receive regular check-ups and care.

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Study details
    Pancreatic Cancer

NCT07173387

Shandong Cancer Hospital and Institute

17 October 2026

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