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Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

Join a study testing DSB2455 for advanced cancer safety and effects.

Recruiting
18 years and older
All
Phase 1

This study is testing a new drug called DSB2455 for people with advanced cancers like breast, prostate, ovarian, or pancreatic cancer. The study has two parts: first, they will find a safe dose, then see how well it works. You can join if you are 18 or older, have specific types of cancer, and are able to follow the study rules. You must have a life expectancy of more than 12 weeks and good organ function.

However, you cannot join if you have certain health issues like blood disorders (myelodysplastic syndrome or acute myeloid leukemia), recent cancer treatments, or active infections.

  • The study lasts several weeks, requiring regular hospital visits.
  • Participants must be willing to undergo medical tests and donate blood samples.
  • There may be risks, and participation is voluntary.

If you meet the criteria and are interested, you need to provide consent and be willing to follow the study procedures carefully. This research could help find better treatments for people with advanced cancer.

Study details
    Advanced Cancers (Breast
    Ovarian
    mCRPC
    Pancreatic Ductal Adenocarcinoma (PDAC)
    Brain Mets) With Specific Mutations (Homologous Recombination Deficiency)

NCT06458712

Duke Street Bio Ltd

12 September 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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