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Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

Trying Riluzole to help with cancer-related memory issues in a study.

Recruiting
18 years and older
All
Phase 2

This study tests if the drug riluzole can help cancer survivors with brain issues called cognitive impairment. Cognitive impairment means having trouble with memory or thinking after cancer treatments. This study is phase 2a, which means it is in an early stage of testing the drug's effects. It's randomized and double-blinded, meaning that neither the participants nor the researchers know who is getting the actual drug or a placebo (a fake treatment). The study checks how riluzole changes BDNF levels, a factor in the blood linked to brain health.

  • The study is for cancer survivors who finished treatment or had brain radiation.
  • Participants must be 18 or older and able to complete questionnaires.
  • Women who are pregnant or breastfeeding cannot join.

If you join, you'll need to complete tests and assessments. It's important to note the risks if you're taking other medications. Always talk to your doctor to see if this study is right for you.

Study details
    Breast Cancer
    Sarcoma
    Gastric Cancer
    Lung Cancer
    Head and Neck Cancer
    Colorectal Cancer
    Ovarian Cancer
    Liver Cancer
    Genitourinary Cancer
    Gynecologic Cancer
    Urinary Bladder Cancer
    Leukemia
    Lymphoid Leukemia
    Myeloma Multiple
    Prostate Cancer
    Pancreas Cancer
    Non-hodgkin Lymphoma
    Hodgkin Lymphoma
    Brain Cancer
    Melanoma
    Mycosis Fungoides
    Kidney Cancer

NCT06580002

University of California, Irvine

31 July 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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