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AB801 in Combination With Chemotherapy and Immunotherapy for the Treatment of Patients With Borderline Resectable, Locally Advanced or Metastatic Cholangiocarcinoma or Pancreatic Cancer

Clinical trial testing AB801 with chemotherapy and immunotherapy for certain cancers.

Recruiting
18 years and older
All
Phase 1
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Study Overview: This research is for adults with certain liver or pancreatic cancers. It tests a new drug, AB801, with chemotherapy and immunotherapy. AB801 blocks a protein called AXL, which helps cancer grow and resist treatment. By blocking AXL, AB801 may help make cancer cells easier to treat. Key Points: - Duration: The study lasts for 24 weeks, with cycles every 21 or 28 days depending on your cancer type. - Visits: Expect regular visits for treatment and scans like CT or MRI to monitor progress. - Compensation & Risks: Discuss risks and any potential compensation with the study team before participating. Eligibility: To join, you must be 18 or older with specific liver or pancreatic cancers, meet health criteria, and provide consent. Women must use contraception if they can become pregnant. Ensure you discuss all personal health concerns with the study team.
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Study details
    Borderline Resectable Pancreatic Ductal Adenocarcinoma
    Locally Advanced Cholangiocarcinoma
    Locally Advanced Pancreatic Adenocarcinoma
    Metastatic Cholangiocarcinoma
    Metastatic Pancreatic Adenocarcinoma
    Stage II Pancreatic Cancer AJCC v8
    Stage III Pancreatic Cancer AJCC v8
    Stage IV Pancreatic Cancer AJCC v8

NCT07619313

Jonsson Comprehensive Cancer Center

4 October 2026

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