This study looks at a new surgery called Total Pancreatectomy with Islet Autotransplantation (TPIAT) for adults with tumors near the pancreas. The goal is to see if this surgery can be a safe option instead of another surgery called pancreaticoduodenectomy, which may cause complications. A total pancreatectomy means removing the whole pancreas, and islet autotransplantation involves moving important cells from the pancreas to another part of the body to help control blood sugar.

Key points to know:

• The study lasts 12 months after surgery.
• Participants will have either open or robotic surgery.
• Participants' health and recovery will be closely monitored.

To join, you need to be at least 18 years old with certain types of pancreatic tumors. Pregnant individuals or those with certain health issues cannot participate. If eligible, participants will undergo surgery and their safety and recovery will be tracked for a year. This study helps researchers understand if TPIAT is a good option for people with high-risk pancreatic tumors.