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A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies

Testing BMS-986523 safety and effects with other cancer treatments.

Recruiting
18 years and older
All
Phase 1/2
This study aims to understand how safe and effective a drug called **BMS-986523** is for people with advanced solid tumors. Solid tumors are abnormal growths of tissue that are usually firm. The study will test BMS-986523 alone and with other cancer-fighting drugs to see how well it works and how patients handle it. To join, participants must have a tumor with a specific change in a gene called **KRAS**. This change can make the tumor hard to treat. People with certain other illnesses or untreated brain tumors cannot join. Participants should have already tried standard treatments or decided not to undergo them. **Key Points:** - **Participation involves**: Different treatment arms and requires a specific kind of tumor. - **Health requirements**: No untreated brain tumors or recent severe skin reactions. - **Study goal**: Check safety and effectiveness of the drug. Remember, it's important to talk to your doctor to understand if participating in this study is right for you and to know more about the potential benefits and risks involved.
Study details
    Advanced Solid Malignancies
    Non-small Cell Lung Cancer (NSCLC)
    Colorectal Cancer (CRC)
    Pancreatic Ductal Adenocarcinoma (PDAC)

NCT07223047

Bristol-Myers Squibb

6 August 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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